THERAPEUTICS

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(2)        Soloviev, M.; Esteves, M. P.; Amiri, F.; Crompton, M. R.; Rider, C. C. Elevated Transcription of the Gene QSOX1 Encoding Quiescin Q6 Sulfhydryl Oxidase 1 in Breast Cancer. PloS One 2013, 8 (2), e57327. https://doi.org/10.1371/journal.pone.0057327.

(3)        Knutsvik, G.; Collett, K.; Arnes, J.; Akslen, L. A.; Stefansson, I. M. QSOX1 Expression Is Associated with Aggressive Tumor Features and Reduced Survival in Breast Carcinomas. Mod Pathol 2016, 29 (12), 1485–1491. https://doi.org/10.1038/modpathol.2016.148.

(4)        Araujo, D. G.; Nakao, L.; Gozzo, P.; Souza, C. D.; Balderrama, V.; Gugelmin, E. S.; Kuczynski, A. P.; Olandoski, M.; de Noronha, L. Expression Level of Quiescin Sulfhydryl Oxidase 1 (QSOX1) in Neuroblastomas. Eur J Histochem 2014, 58 (1), 2228. https://doi.org/10.4081/ejh.2014.2228.

(5)        Lake, D. F.; Faigel, D. O. The Emerging Role of QSOX1 in Cancer. Antioxid Redox Signal 2014. https://doi.org/10.1089/ars.2013.5572.

(6)        Shi, C. Y.; Fan, Y.; Liu, B.; Lou, W. H. HIF1 Contributes to Hypoxia-Induced Pancreatic Cancer Cells Invasion via Promoting QSOX1 Expression. Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol. 2013, 32 (3), 561–568. https://doi.org/10.1159/000354460.

(7)        Song, H.; Zhang, B.; Watson, M. A.; Humphrey, P. A.; Lim, H.; Milbrandt, J. Loss of Nkx3.1 Leads to the Activation of Discrete Downstream Target Genes during Prostate Tumorigenesis. Oncogene 2009, 28 (37), 3307–3319. https://doi.org/10.1038/onc.2009.181.

(8)        Antwi, K.; Hostetter, G.; Demeure, M. J.; Decker, G. A.; Ruiz, Y.; Sielaff, T.; Koep, L.; Lake, D. F. Analysis of Human Plasma Peptidome Reveals Potential Biomarker for Pancreatic Cancer. J Proteome Res 2009, 8, 4722–4731.

(9)        Thorpe, C.; Hoober, K. L.; Raje, S.; Glynn, N. M.; Burnside, J.; Turi, G. K.; Coppock, D. L. Sulfhydryl Oxidases: Emerging Catalysts of Protein Disulfide Bond Formation in Eukaryotes. Arch. Biochem. Biophys. 2002, 405 (1), 1–12. https://doi.org/10.1016/S0003-9861(02)00337-5.

(10)      Rancy, P. C.; Thorpe, C. Oxidative Protein Folding in Vitro: A Study of the Cooperation between Quiescin-Sulfhydryl Oxidase and Protein Disulfide Isomerase. Biochemistry 2008, 47 (46), 12047–12056. https://doi.org/10.1021/bi801604x.

(11)      Raje, S.; Glynn, N. M.; Thorpe, C. A Continuous Fluorescence Assay for Sulfhydryl Oxidase. Anal Biochem 2002, 307 (2), 266–272. https://doi.org/S0003269702000507 [pii].

(12)      Hanavan, P. D.; Borges, C. R.; Katchman, B. A.; Faigel, D. O.; Ho, T. H.; Ma, C. T.; Sergienko, E. A.; Meurice, N.; Petit, J. L.; Lake, D. F. Ebselen Inhibits QSOX1 Enzymatic Activity and Suppresses Invasion of Pancreatic and Renal Cancer Cell Lines. Oncotarget 2015.

(13)      Katchman, B. A.; Antwi, K.; Hostetter, G.; Demeure, M. J.; Watanabe, A.; Decker, G. A.; Miller, L. J.; Von Hoff, D. D.; Lake, D. F. Quiescin Sulfhydryl Oxidase 1 Promotes Invasion of Pancreatic Tumor Cells Mediated by Matrix Metalloproteinases. Mol. Cancer Res. MCR 2011, 9 (12), 1621–1631. https://doi.org/10.1158/1541-7786.MCR-11-0018.

(14)      Ilani, T.; Alon, A.; Grossman, I.; Horowitz, B.; Kartvelishvily, E.; Cohen, S. R.; Fass, D. A Secreted Disulfide Catalyst Controls Extracellular Matrix Composition and Function. Science 2013. https://doi.org/10.1126/science.1238279.

(15)      Israel, B. A.; Jiang, L.; Gannon, S. A.; Thorpe, C. Disulfide Bond Generation in Mammalian Blood Serum: Detection and Purification of Quiescin-Sulfhydryl Oxidase. Free Radic. Biol. Med. 2014, 69, 129–135. https://doi.org/10.1016/j.freeradbiomed.2014.01.020.

(16)      Garcia, B. L.; Skaff, D. A.; Chatterjee, A.; Hanning, A.; Walker, J. K.; Wyckoff, G. J.; Geisbrecht, B. V. Identification of C3b-Binding Small Molecule Complement Inhibitors Using Cheminformatics. J. Immunol. Baltim. Md 1950 2017, 198 (9), 3705–3718. https://doi.org/10.4049/jimmunol.1601932.

(17)      Viegas, A.; Manso, J.; Nobrega, F. L.; Cabrita, E. J. Saturation-Transfer Difference (STD) NMR: A Simple and Fast Method for Ligand Screening and Characterization of Protein Binding. J. Chem. Educ. 2011, 88 (7), 990–994. https://doi.org/10.1021/ed101169t.